UA94/6/1 Gemini 14 USO Show

Press kit created by the USO to promote Gemini 14. Includes photo of the band, list of members, set list and biographical sketches of members

Gemini 14 Memories

Answers given by Nancy (Hill) Cron to WKU Gemini jazz bands questionnaire in spring of 2016. See Gemini Jazz Bands online exhibit for more information

An Assessment of the Human Papillomavirus Immunization Knowledge, Practices, and Prevention Among a Cohort of Urban College Students

Human papillomavirus (HPV) is the most common sexually transmitted disease, yet little is known about the college-age knowledge and prevention practices related to HPV. Although sample vaccination rates mirrored national known vaccination rates, a majority of participants did not complete the three dose vaccine schedule. HPV knowledge was similar between males and females while males were more likely to engage in preventative practices. This information can help healthcare providers reinforce vaccination schedule and prevention practices

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Panama Canal

A Danish ship in the Panama Canal. This photograph was taken by Nancy Cron when she was a member of the Gemini 14 Jazz Band touring in the Caribbean.https://digitalcommons.wku.edu/seven_con_southam/1002/thumbnail.jp

Gemini 14 Caribbean Trip

Afternoon show at hospital. Please comment below if you can identify anyone in the photograph. UA1C11/83/1 Nancy Cron Photo Collection donated by Nancy Cron.https://digitalcommons.wku.edu/gjb/1010/thumbnail.jp

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/1/art42037.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/2/art42037-sup-0001-Disclosureform.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172047/3/art42037_am.pd

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/1/acr24853.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/2/acr24853_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/172074/3/acr24853-sup-0001-Disclosureform.pd